Insightful Life Sciences Solutions Resources

Presentations Available for Download:

• Best Practice for Graphics from Clinical Trials
  Peter Lane, Research Statistics Unit, GlaxoSmithKline
• Clinical Data Analysis and Reporting with S-PLUS
  Michael O'Connell, Insightful Corporation
• Visualize Data in Population and PK/PD Analysis for Exposure Response, Simon Zhou, Wyeth Research
• Automated Creation of Pharmacokinetic Report Tables and Figures with S-PLUS
  Susan E. Shoaf, Otsuka Maryland Research Institute
• Phase 2 Study Design: Optimal Dose-Selection
  Patrick Johnson, Pharmacometrics, Clinical Statistics, Pfizer GR&D
• Modeling Clinical Data to Create Biomarkers for Prediction of Outcomes
  Alan Hochberg, Prosanos Corporation
• “Standard” Clinical Pharmacology Studies: Optimizing Reporting Workflow With S-PLUS
  Keith Nieforth, Hoffman- La Roche
• Case Studies in Group Sequential Clinical Trial Design: Stopping Rules for Pivotal Studies and Combined Noninferiority/Superiority Trials
  Scott Emerson, M.D., Ph.D., Professor of Biostatistics, University of Washington
• Using Simulation and Graphics as an Aid in Planning Complicated Experiments
  Dr. William Q. Meeker, Iowa State University
• Redesigning A Clinical Trial Using Bayesian Criteria
  Scott Emerson, University of Washington

On-demand Web Casts

• Insightful Solutions for Statistical Modeling and Graphical Analysis of Safety Data in Clinical Trials
  Michael O'Connell, Insightful Corporation
  
• Subgroup Analyses in Clinical Trials: Can We Smooth Out the Rough Edges?
  Daniel Sargent, Mayo Clinic
  
• Statistical Graphics Mashups for Analysis, Review and Reporting
  Michael O'Connell, Insightful Corporation
  
• MCPMod: A Library for the Design and Analysis of Dose Finding Trials
  Jose Pinheiro, Novartis
  
• Understanding Patient Safety Through Use of Statistical Graphics
  Ohad Amit, GlaxoSmithKline
  
• FDA Review and CDISC Data and Metadata Standards
  Joel Hoffman, Insightful Corporation
  
• Sequential Clinical Trial Design with Survival Endpoints Part 2: Monitoring, Reporting and Flexible Accrual, Time-to-Event, and Dropout
  Dr. Daniel Gillen, University of California at Irvine
  
• S-PLUS Graphics in Medical Research
  Dr. Kye Gilder, Biogen Idec
  
• Sequential Clinical Trial Design with Survival Endpoints Part 1
  Dr. Daniel Gillen, University of California at Irvine
  
• Statistical Modeling and Graphical Analysis of Safety Data in Clinical Trials
  Michael O'Connell, Insightful Corporation
  
• Visualize Data in Population and PK/PD Analysis for Exposure Response
  Simon Zhou, Wyeth Research
  
• Structured Sets of Graphs
  Richard Heiberger and Burt Holland, Temple University
  
• Clinical PK Graphical and Tabular Reporting using S-PLUS
  Michael O'Connell, Insightful Corporation
  
• Statistical Graphics for the Design and Analysis of Clinical Development Studies
  Michael O'Connell, Insightful Corporation
  
• Creating More Effective Graphs
  Naomi Robbins, NBR
  
• Group Sequential and Adaptive Clinical Trial Design
  Dr. Scott Emerson, University of Washington
  
• Pre-Analytic and Post-Analytic Factors in Postmarket Drug Safety Data Mining
  Alan Hochberg, ProSanos Corporation
  
• Safety Data Analysis and Reporting: Signal Detection, Data-mining and Next Generation Methodology for Drug Risk Assessment and Safety Research
  Alejandro Murura, University of Montreal
  
• Safety Data Analysis and Reporting using S-PLUS® and Insightful Miner™
  Michael O'Connell, Insightful Corporation
  

External Resources

• Xpose by Niclas Jonsson (S-PLUS population PK/PD model building aid for NONMEM)
• S-PLUS Functions for Epidemiologic Analyses by Norman Breslow and colleagues